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Many medical conditions can affect the shape or texture of the fingernails. Brittleness of the nails, meaning that the nails easily become cracked or chipped, can be observed as a sign of aging or in response to the long-term use of nail polish or exposure to moist conditions (including frequent swimming or dishwashing). Some diseases are also associated with changes in the nails, which can include brittleness.

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Swelling of the lymph glands is typically a result of local or widespread inflammation, but sometimes enlarged lymph nodes are due to cancer. Swollen lymph glands are referred to as lymphadenopathy. Inflammation of a lymph node is referred to as lymphadenitis.

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